Leslie L. Heckert

Our laboratory is studying the molecular mechanisms that regulate cellular differentiation and organ development of the reproductive system. We are interested in the transcriptional and cell-signaling processes involved in activating and regulating genes important for the development and function of the testis and their implications in sex determination. In particular, we are studying the processes that control testis- or gonad-specific expression of three genes that are critical for proper fetal development and/or gonad function. These are: 1) doublesex and mab-3 related transcription factor 1, an evolutionarily conserved protein that is required for testis differentiation, 2) steroidogenic factor 1, a protein that is required for the formation of adrenal glands and gonads, and 3) follicle stimulating hormone receptor, a protein expressed only in somatic cells of the gonads and is required for endocrine regulation of the testis and ovary. My laboratory employs a variety of experimental approaches that include cell culture, molecular biology, and transgenic and knockout mice. Through these studies, we hope to provide insight into the genetic events necessary for formation and function of the gonads, thus expanding our understanding of the biological requirements for organ development and reproduction.